Amiodarone Deal - Don't Overpay At The Pharmac

  1. Read This Before Taking - All Potential Side Effects of Amiodarone
  2. Amiodarone is used to treat ventricular tachycardia or ventricular fibrillation. Amiodarone is for use only in treating life-threatening heart rhythm disorders
  3. Amiodarone is used to treat and prevent certain types of serious, life-threatening ventricular arrhythmias (a certain type of abnormal heart rhythm when other medications did not help or could not be tolerated. Amiodarone is in a class of medications called antiarrhythmics. It works by relaxing overactive heart muscles
  4. Amiodarone is an antiarrhythmic medication used to treat and prevent a number of types of irregular heartbeats. This includes ventricular tachycardia (VT), ventricular fibrillation (VF), and wide complex tachycardia, as well as atrial fibrillation and paroxysmal supraventricular tachycardia. Evidence in cardiac arrest, however, is poor
  5. Amiodarone is known as an anti-arrhythmic drug. It works by blocking certain electrical signals in the heart that can cause an irregular heartbeat. How to use Amiodarone HCL Read the Medication..
  6. Amiodarone belongs to the group of medicines known as antiarrhythmics. It works directly on the heart tissue and will slow the nerve impulses in the heart. This helps keep your heart rhythm normal. This medicine is available only with your doctor's prescription
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Amiodarone affects the rhythm of your heartbeats

Amiodarone Warning Effect - Warnings Side Effects and Mor

Amiodarone (Cordarone, Pacerone) is an effective and commonly prescribed antiarrhythmic drug, but it has some marked differences from many other drugs. If your doctor prescribes this medicine for cardiac arrhythmia, you need to understand the idiosyncrasies—and the risks—associated with it. Jose Luis Pelaez Inc. / Getty Image Amiodarone is an iodine-rich benzofuran derivative with antiarrhythmic and vasodilatory activities. As a class III antiarrhythmic agent, amiodarone blocks the myocardial calcium, potassium and sodium channels in cardiac tissue, resulting in prolongation of the cardiac action potential and refractory period. In addition, this agent inhibits alpha- and beta-adrenergic receptors, resulting in a.

Amiodarone Uses, Dosage & Side Effects - Drugs

Amiodarone: MedlinePlus Drug Informatio

Amiodarone, a bi-iodinated benzofuran derivative, is, because of its high effectiveness, one of the most widely used antiarrhythmic agents. However, adverse effects, especially potentially fatal and non-reversible acute and chronic pulmonary toxicity, continue to be observed Amiodarone is a potent antiarrhythmic drug, widely used in the treatment of atrial fibrillation as well as of life-threatening ventricular or supra-ventricular arrhythmias and to prevent sudden death in selected patients. However, the drug has side effects on several tissues, including the thyroid gland Amiodarone can cause numerous kinds of lung problems, but in most cases, the problem takes one of four forms. The most dangerous type of amiodarone lung toxicity is a sudden, life-threatening, diffuse lung problem called acute respiratory distress syndrome (ARDS). With ARDS, damage occurs to the membranes of the lung's air sacs, causing the. Amiodarone is used to treat irregular heartbeats. Treatment with it will be started by a heart specialist. It is very important that you take amiodarone exactly as your doctor tells you to. You will be started on a high dose, for one week only. Your dose will then be reduced over the following two weeks to a maintenance dose

Amiodarone - Wikipedi

FDA Announces Amiodarone Recall! On August 31 st, the FDA announced that Mylan N.V. was recalling several lots of amiodarone. Mylan is a multi-billion dollar Dutch pharmaceutical company and one of several manufacturers of amiodarone. According to the FDA, Mylan has recalled four lots of Amiodarone HCl Injection and Tranexamic Acid Injection Amiodarone is an antiarrhythmic that can be used to treat abnormal heart rhythms like ventricular tachycardia, where the heart beats really fast due to a problem arising in the ventricles of the. Amiodarone is a substrate for CYP3A and CYP2C8, so inhibitors and inducers affect amiodarone exposure. Amiodarone inhibits p‐glycoprotein and CYP1A2, CYP2C9, CYP2D6, and CYP3A, increasing exposure to other drugs

Patients usually have no visual symptoms. May rarely report mildly blurred vision or haloes. Curved golden brown or gray-white lines originate below center of cornea in both eyes. Visible to naked eye but better seen with slit lamp. Corneal whorls are subepithelial phospholipid deposits Amiodarone HCl is (2-butyl-3-benzofuranyl)[4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl]methanone hydrochloride. Amiodarone HCl has the following structural formula: Amiodarone HCl is a white to slightly yellow crystalline powder, and is very slightly soluble in water. It has a molecular weight of 681.78 and contains 37.3% iodine by weight. Cordarone (Amiodarone) is an option to treat heart rate problems when other medicines don't work, but it can take a few weeks to work and there's a lot of serious side effects. Not a good choice if you have eye, liver, or lung problems Amiodarone pulmonary toxicity can present in various ways: pneumonia interstitial disease, respiratory distress or solitary pulmonary masses. Clinical scenarios are variable, the most common symptoms being dyspnea and dry cough, but symptoms can also include fever, weight loss, hemoptysis and chest pain aggravated by breathing movements.. Amiodarone affects the rhythm of your heartbeats.. Amiodarone is used to help keep the heart beating normally in people with life-threatening heart rhythm disorders of the ventricles (the lower chambers of the heart that allow blood to flow out of the heart). Amiodarone is used to treat ventricular tachycardia or ventricular fibrillation.. Amiodarone is for use only in treating life.

Summary. Amiodarone is a class III antiarrhythmic agent that blocks voltage-gated potassium channels. It is used in the treatment of acute ventricular tachycardia and persisting ventricular fibrillation after unsuccessful defibrillation, as well as the long-term treatment of refractory supraventricular arrhythmia (atrial fibrillation).Since amiodarone has a very low negative inotropic effect. Amiodarone Hydrochloride is the hydrochloride salt of an iodine-rich benzofuran derivative with antiarrhythmic and vasodilatory activities. As a class III antiarrhythmic agent, amiodarone blocks the myocardial calcium, potassium and sodium channels in cardiac tissue, resulting in prolongation of the cardiac action potential and refractory period. In addition, this agent inhibits alpha- and.

Digoxin and amiodarone are heart medications used to treat abnormal heart rhythms and congestive heart failure. Digoxin also is used for increasing myocardial contractility in pediatric patients with heart failure. Learn side effects, drug interactions, dosages, and more Cordarone (amiodarone HCl) is a member of a new class of antiarrhythmic drugs with predominantly Class III (Vaughan Williams' classification) effects, available for oral administration as pink, scored tablets containing 200 mg of amiodarone hydrochloride Amiodarone blocks sodium channels at rapid pacing frequencies and exerts a non-competitive antisympathetic action. One of its main effects, with prolonged administration, is to lengthen the cardiac action potential. In addition, it produces a negative chronotropic effect in nodal tissues

Dose: 200 mg PO qd; Start: load 600-800 mg/day PO divided bid-tid up to 10 g total; Info: give w/ meals if GI intolerance. [rate control, IV route] Dose: 300 mg IV over 1h, then 10-50 mg/h IV x24h. [rate control, PO route] Dose: 100-200 mg PO qd; Info: give w/ meals if GI intolerance. [rhythm control, IV route] Dose: 150 mg IV x1 over 10min. Amiodarone is generally considered a class III antiarrhythmic drug, but it possesses electrophysiologic characteristics of all four Vaughan Williams classes. Like class I drugs, amiodarone blocks sodium channels at rapid pacing frequencies, and like class II drugs, it exerts a noncompetitive antisympathetic action Hypersensitivity to amiodarone, or benzyl alcohol; cardiogenic shock, severe sinus bradycardia, advanced AV block unless a pacemaker is available, severe sinus-node dysfunction or sick sinus syndrome, bradycardia, congenital or acquired QR prolongation syndromes, or history of torsade de pointes; severe liver disease, children Amiodarone is an antiarrhythmic agent commonly used to treat supraventricular and ventricular arrhythmias. This drug is an iodinecontaining compound that tends to accumulate in several organs, including the lungs. It has been associated with a variety of adverse events. Of these events, the most ser

Amiodarone. Amiodarone is an antiarrhythmic agent with a complex mechanism of action and many effects. K + channel blockade in cardiac myocytes, inhibiting the slow outward current and slowing repolarisation (Class III); β-blocker-like activity on SA and AV nodes, decreasing automaticity and slowing nodal conduction (Class II Amiodarone has a long half-life, up to 100 days, because it's lipophilic and stored in adipose tissue. 8, 10 Thus, deposits of amiodarone with iodine can take months to be eliminated. 9 The effect that amiodarone has on thyroid hormone secretion depends on the dose and duration of treatment. 9 Usually, T 3 levels decrease and T 4, free T 4, and. Amiodarone can prolong AV conduction, the AV refractory period, and QRS and QT intervals—ultimately slowing the heart rate. Amiodarone is a well known multi channel blocker, because it blocks sodium, potassium, and calcium channels and is an alpha and beta blocker. Amiodarone Indications for Use: Amiodarone is an antiarrhythmic drug

Amiodarone: Belongs to class III antiarrhythmics., Sinus bradycardia, sino-atrial heart block, severe conduction disturbances (e.g. high-grade AV block, bifascicular or trifascicular block) without a presence of pacemaker, cardiogenic shock, severe hypotension, severe respiratory failure, known or history of thyroid dysfunction, known hypersensitivity to iodine, corneal refractive laser surgery Amiodarone is a di-iodinated benzofuran derivative developed for the treatment of angina pectoris in the 1960s (1). By 2000, it had become the most commonly prescribed antiarrhythmic drug in North America with over 400,000 individuals receiving amiodarone for the treatment of atrial fibrillation alone (2)

Amiodarone Oral: Uses, Side Effects, Interactions

Amiodarone and its metabolite have been shown to cross the placenta; adverse fetal effects associated with maternal amiodarone use during pregnancy may include neonatal bradycardia, QT prolongation, and periodic ventricular extrasystoles, neonatal hypothyroidism (with or without goiter) detected antenatally or in the newborn and reported even. Amiodarone (Cordarone) is a commonly prescribed medication for the management of both atrial and ventricular arrhythmias. Unfortunately, when amiodarone is given to a euthyroid (normal thyroid function) patient , the normal physiologic process for the formation of the thyroid hormones, thyroxine (T4) and 3,5,3'-triiodothyronine (T3), can be adversely affected Amiodarone Substrate Information Inhibitor Information Clinical Drug-drug Interactions In Vitro Substrates. No substrate information. Back to top In Vitro Inhibitors * denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporte

Amiodarone ppt 1. Antiarrhythmic agent Class 2. Potent antiarrhythmic agent and the first- line antiarrhythmic agent given during cardiac arrest. Has been clinically demonstrated to improve the rate of ROSC and hospital admission in adults with refractory ventricular fibrillation and pulseless ventricular tachycardia. D OBJECTIVE: To assess whether amiodarone, as part of a strategy to achieve sinus rhythm, is safe and effective compared with a placebo or rate control drug in patients with persistent atrial fibrillation (AF) of more than 30 days' duration. METHODS: Randomized controlled trials comparing amiodarone.

Amiodarone, a class III antiarrhythmic, has become the drug of choice for the management of supraventricular and ventricular arrhythmias. 1,2 Although not an FDA- approved indication, the use of amiodarone to treat atrial fibrillation is supported by practice guidelines from the American College of Cardiology/ American Heart Association (AHA) and the European Society of Cardiology. 3 The AHA. Overview: Amiodarone is a Class III antiarrhythmic medication that slows repolarization of the myocardium which increases the action potential duration and the refractory period, thus slowing the cardiac conduction rate. It is used to treat certain tachyarrhythmias. Long-term use is associated with the following ocular adverse effects

Amiodarone (Oral Route) Description and Brand Names - Mayo

Amiodarone can slow down the removal of other medications from your body, which may affect how they work. Examples of affected drugs include clopidogrel, phenytoin, certain statin drugs (atorvastatin, lovastatin), trazodone, warfarin, among others. Overdose Amiodarone is a primarily a class III antiarrhythmic. Like other antiarrhythmic drugs of this class, amiodarone works primarily by blocking potassium rectifier currents that are responsible for the repolarization of the heart during phase 3 of the cardiac action potential. This potassium channel-blocking effect results in increased action. Amiodarone. The FDA is very clear that there is no evidence from controlled trials that the use of amidarone favorably affects survival.. The agency makes it quite clear that amiodarone side effects are very serious so the drug should only be prescribed when other treatments have failed. The FDA also states clearly that patients should. Hepatotoxicity Amiodarone is also associated with hepatotoxicity and treatment should be discontinued if severe liver function abnormalities or clinical signs of liver disease develop. Pulmonary toxicity Pneumonitis should always be suspected if new or progressive shortness of breath or cough develops in a patient taking amiodarone

An 81-year old man developed acute respiratory distress syndrome (ARDS) during treatment with amiodarone for atrial fibrillation. The man, who had a history of atrial fibrillation, diabetes and mechanical aortic valve replacement, presented to the hospital with 4 week history of dry cough and 1 week history of dyspnoea on exertion amiodarone dosing. Initial IV dosing. Load with 150 mg bolus, then infuse at 1 mg/minute. May re-load 1-2 times if inadequate response (for a total of 150-450 mg given in the form of boluses). Conversion to oral. Infusion may be converted to oral administration after >24 hours Amiodarone hydrochloride is a benzofuran derivative: 2-butyl-3-benzofuranyl 4-[2-(diethylamino)-ethoxy]- 3,5-diiodophenyl ketone hydrochloride. The structural formula is as follows: C 25 H 29 I 2 NO 3 ·HCl Molecular Weig ht: 681.8. Amiodarone hydrochloride is a white to cream-colored crystalline powder Amiodarone is one the most frequently prescribed antiarrhythmic drugs for atrial fibrillation. 5 It is used by 8-11% of patients. 6. Atrial fibrillation is the commonest arrhythmia in older adults, with an estimated prevalence of 9% in people over the age of 80 years The man's amiodarone therapy was stopped, and his treatment was started with unspecified steroids. During follow-up examination after three months, resolution of cough, hypoxaemia, dyspnoea, pleural effusion, lung hyper-attenuation and the pulmonary masses (lipoid and cryptogenic organizing pneumonia) was noted

AMIODARONE (a MEE oh da rone) is an antiarrhythmic drug. It helps make your heart beat regularly. Because of the side effects caused by this medicine, it is only used when other medicines have not worked. It is usually used for heartbeat problems that may be life threatening Amiodarone prescription and dosage sizes information for physicians and healthcare professionals. Pharmacology, adverse reactions, warnings and side effects Amiodarone is considered to be the most effective antiarrhythmic drug in the prevention of persistent atrial fibrillation. It can however cause many adverse events, both cardiac and non-cardiac. Long-term maintenance of sinus rhythm after cardioversion is difficult especially because of high recurrence rates during the first month after.

Amiodarone (Oral Route) Side Effects - Mayo Clini

Amiodarone comes as a tablet which can be taken once or twice a day with food or on an empty stomach. Follow the instructions exactly as guided. Read the prescription label completely and follow. Treatment with Class I or III antiarrhythmics (e.g., amiodarone, flecainide, propafenone, quinidine, disopyramide, dofetilide, sotalol) or drugs that are strong inhibitors of CYP3A (e.g., ketoconazole) must be stopped before starting MULTAQ [see Contraindications (4)] Amiodarone is a medication that has been approved by the FDA to treat irregular heart rhythms, including atrial fibrillation and atrial flutter. Amiodarone is also sold under the brand-names Pacerone, Cordarone, and Aratac. It is also frequently prescribed off-label for conditions not approved by the FDA

Amiodarone is also toxic to the skin and lungs. Pulmonary toxicity is more common in older people, and it increases threefold every 10 years of age in patients over 60. If these lung problems develop into pneumonia, the death rate is around 9% in patients taking amiodarone. Amiodarone impairs the metabolism, which can make patients much more. Overall, neither amiodarone nor lidocaine resulted in a significantly higher rate of survival or favorable neurologic outcome than the rate with placebo among patients with out-of-hospital cardiac.

Baxter Nexterone (Amiodarone HCI) Premixed Injection

Amiodarone is used to control an irregular or fast heart rate, including a condition called atrial fibrillation (AF). It works by slowing the electrical signals sent through the heart. In New Zealand, amiodarone is available as tablets (100 milligram or 200 milligram) and as an injection that is used in hospitals Drug Name Generic Name: amiodarone hydrochloride Brand Name: Cordarone, Pacerone Classification: Antiarrhythmic, Adrenergic blocker (not used as sympatholytic drug) Pregnancy Category D Dosages Careful patient assessment and evaluation with continual monitoring of cardiac response are necessary for titrating the dosage. Therapy should begin in the hospital with continual monitoring and. Amiodarone (Cordarone) received an overall rating of 4 out of 10 stars from 15 reviews. See what others have said about Amiodarone (Cordarone), including the effectiveness, ease of use and side effects amiodarone Cordorone ® Cardiology A class III agent that prolongs the duration of the action potential; amiodarone is used to treat refractory ventricular and supraventricular tachycardia, A Fib, conduction block Adverse effects Pulmonary fibrosis, which occurs in ±6% of Pts taking the drug, hypothyroidism, hyperthyroidism, deposits in cornea—causing photosensitivity and/or skin-blue/gray.

Cornea verticillata

Amiodarone Side Effects, Dosage, Uses & Mor

Amiodarone lung toxicity is a diagnosis of exclusion, and treatment includes simply withdrawing amiodarone, though steroids can be used in severe cases. A majority of patients improve. Noun: 1. amiodarone - an antiarrhythmic drug (trade name Cordarone) that has potentially fatal side effects and is used to control serious heart rhythm problems only when safer agents have been ineffectiv Multaq (Dronedarone) 1 of 3 alternatives. Treats heart rate problems. Cordarone (Amiodarone) is an option to treat heart rate problems when other medicines don't work, but it can take a few weeks to work and there's a lot of serious side effects. No information currently available

Amiodarone pulmonary toxicity:a report on two casesTreatment with amiodarone: How to avoid complications

Amiodarone (Nexterone): Side Effects, Dosages, Treatment

Amiodarone was initially developed in the early 1960s as a treatment for angina pectoris, since it produces coronary vasodilation and decreases cardiac oxygen demand. However, its pronounced antiarrhythmic effects redirected its use and amiodarone has become a widely used class III anti-arrhythmic drug. Compared to other antiarrhythmic drugs, it is more effective in treating both. Amiodarone hydrochloride is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca 2+ in Saccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.Amiodarone hydrochloride has also been used in a study to determine concentrations of thyroid disrupting substances in effluents from wastewater treatment plants Amiodarone is a cardiac drug that is indicated for the management of life-threatening recurrent ventricular fibrillation (VF) or hemodynamically-unstable ventricular tachycardia (VT) refractory to. At steady-state, the metabolite concentration is similar to the amiodarone concentration. This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical. The results of several small studies suggest that amiodarone may be beneficial in the treatment of patients with recent infarction. 15,16 Amiodarone is a powerful antiarrhythmic agent that.

Amiodarone: Guidelines for Use and Monitoring - American

Although amiodarone is regarded as a highly effective anti-arrhythmic agent, its use may lead to alterations in thyroid gland function and/or thyroid hormone metabolism, partly because of its rich iodine content. Patients treated with amiodarone may manifest altered thyroid hormone profile without thyroid dysfunction, or they may present with clinically significant amiodarone-induced. An Overview of Amiodarone Interactions. Amiodarone ( Cordarone ®, Pacerone ®, Nexterone ®) can potentially interact with a few other medications. Some of the products that may lead to drug interactions with amiodarone include but are not limited to: Azithromycin ( Zithromax ®) Beta blockers, such as: Acebutolol ( Sectral ®) Atenolol. Amiodarone-Trade names. Click card to see definition . Tap card to see definition . Cordarone, Pacerone. Click again to see term . Tap again to see term . Nice work! You just studied 10 terms! Now up your study game with Learn mode Substitute Drug for Amiodarone. If your heart rhythm problem is not adequately controlled or if you develop severe side effects with amiodarone ( Cordarone ®, Pacerone ®, Nexterone ® ), your healthcare provider may recommend a substitute antiarrhythmia drug. Some of the possible alternatives to amiodarone include: Propafenone ( Rythmol. AMIODARONE Class: Antiarrhythmic Agent, Class III Indications: Management of life-threatening recurrent ventricular fibrillation (VF) or hemodynamically-unstable ventricular tachycardia (VT) refractory to other antiarrhythmic agents or in patients intolerant of other agents used for these condition

Amiodarone: Antiarrhythmic Medicatio

Amiodarone is an antiarrhythmic drug with structural similarities to thyroxine. It exhibits all four of the classic Vaughan Williams mechanisms of action, namely sodium and potassium channel blockade, a mild antisympathetic action and some calcium channel blockade, but it is usually classified as a Class III antiarrhythmic drug (see Table 1).It prolongs the refractory period in all cardiac. Amiodarone hydrochloride is a broad-spectrum ion channel blocker; blocks late I Na, I Ca, I Kr and I Ks and increases QT. Displays class III antiarrhythmic properties. Also exhibits fungicidal activity; elicits Ca 2+ influx in Saccharomyces cerevisiae and causes mitochondrial fragmentation and cell death Amiodarone Stories. 270 likes · 3 talking about this. Patients and families tell their story of how the toxic drug amiodarone has effected them

amiodarone (Cordarone): Arrhythmia Drug Side Effects

What are the Actions of Amiodarone (Cordarone) Nursing Pharmacology Considerations? prolongs phase 3 of the action potential, makes the heart more tolerant to arrythmias, inhibits. adrenergic stimulation, slows rate, decreases peripheral vascular resistance causing vasodilation Amiodarone is effective for maintaining sinus rhythm but has greater toxicities than other antiarrhythmics used for atrial fibrillation. Amiodarone may be a reasonable first-line agent in patients with concomitant heart failure or substantial left ventricular hypertrophy if rhythm control is preferred over rate control

Unusual Features and Side Effects of Amiodaron

• Amiodarone is a substrate for CYP3A and CYP2C8, so inhibitors and inducers affect amiodarone exposure. (7) • Amiodarone inhibits -glycoprotein and CYP1A2, CYP2C9, CYP2D6, P and CYP3A, increasing exposure to other drugs. (7) -----USE IN SPECIFIC POPULATIONS ----- • Pregnancy: May cause fetal harm.. AMIODARONE (Cordarone) Name: AMIODARONE (CordaroneR) Classification: antiarrhythmic: Class III. prolongs refractory period in atria and ventricles thus effective for arrhythmias of various origins. decreases SA automaticity and conduction through AV node. Dose: Multiple dosing regimes in literature; RECOMMEND Amiodarone Induced Pulmonary Toxicity. Amiodarone is a very dangerous drug. My father, a retired OBGYN, woke. up on January 1 2004, his 69th Birthday, with a temp of 100, general. malaise, and sore throat. Typical symptoms of the cold that was going. around at the Holidays. He stayed in bed and missed his Birthday Party Amiodarone is a highly effective agent for the prophylaxis and treatment of many cardiac rhythm disturbances, ranging from paroxysmal atrial fibrillation to life threatening ventricular tachyarrhythmias.1 Unlike many other antiarrhythmic drugs, amiodarone appears to be safe in patients with significant left ventricular dysfunction,2-5 and may confer prognostic benefit in some patient subgroups. amiodarone hydrochloride Amyben (UK), Cordarone, Cordarone X (UK), Nexterone, Pacerone Pharmacologic class: Benzofuran derivative Therapeutic class: Antiarrhythmic (class III) Pregnancy risk category D FDA Box Warning Oral products • Because of substantial toxicity, drug is indicated only in patients with life-threatening arrhythmias. • Drug may.

Silver nitrate - wikidocEyeRoundsAntiarrhythmics - Cardiovascular - Medbullets Step 1

Amiodarone remains a highly effective drug capable of treating life threatening arrhythmias. Not only does Amiodarone reduce the risk of ventricular rhythm d.. Amiodarone hydrochloride is an antiarrhythmic drug, available for oral administration as white to off-white, scored tablets containing 200 mg of amiodarone hydrochloride USP. The inactive ingredients present are colloidal silicon dioxide, lactose monohydrate, magnesium stearate, povidone, and sodium starch glycolate Amiodarone is a benzofuranic-derivative iodine-rich drug widely used for the treatment of tachyarrhythmias and, to a lesser extent, of ischemic heart disease. It often causes changes in thyroid function tests (typically an increase in serum T 4 and rT 3, and a decrease in serum T 3, concentrations), mainly related to the inhibition of 5. Extravasation of amiodarone can cause significant tissue damage including necrosis. Asymptomatic blue-grey discolouration of exposed areas can also occur. IV loading should only be performed when a rapid response is required. IV amiodarone must be administered via a central line. The only exception is the treatment of cardia Amiodarone is usually initiated in secondary care or under specialist supervision. However, primary care practitioners may be expected to continue prescribing amiodarone and to monitor the person for adverse effects (depending on locally agreed shared care guidelines). The usual maintenance dose is 200 mg a day, or less if appropriate

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